• Email: wychen624@gs.ncku.edu.tw

    陳威宇 (Wei-Yu Chen, Ph.D.)

    Education
    Ph.D. (2009)

    Institute of Basic Medical Sciences, National Cheng Kung University

    國立成功大學基礎醫學研究所

     

    Experiences
    Associate Professor (2022.8-present)

    Department of Biochemistry and Molecular Biology, National Cheng Kung University

    國立成功大學醫學院生物化學暨分子生物學研究所

     

    Associate Research Fellow (2019.8-2022.7)
    Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital

    高雄長庚紀念醫院生物醫學轉譯研究所

     

    Assistant Research Fellow (2014.2-2019.7)

    Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital

    高雄長庚紀念醫院生物醫學轉譯研究所

     

    Postdoctoral Research Fellow (2011.8-2014.1)

    Brigham & Women's Hospital, Harvard Medical School

     

    Awards

    Outstanding Alumni, National Chi-Nan University (國立暨南國際大學傑出校友, 2019)

    MOST Ta-You Wu Memorial Award (科技部吳大猷先生紀念獎, 2019)

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  • Research Interests

    Immunology, Cardiovascular and renal diseases, Disease animal models, Tissue fibrosis

    免疫學、心血管與腎臟疾病、疾病動物模式、組織纖維化
     

    In our lab, we use genetically modified animals, disease animal models, and multi-omics approaches to investigate the immune regulation of tissue reparative responses following acute cardiac or kidney injury

    應用基因修飾小鼠、疾病動物模式、多體學分析等策略研究心臟或腎臟組織損傷後,免疫系統參與組織修復反應之調控,並尋找具有潛力的治療標的
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    Ongoing project

    Study of Interleukin-33-regulated immune network in acute myocardial injury and chronic kidney disease-associated cardiomyopathy progression

    介白素-33媒介之免疫調節網絡於急性心肌損傷與慢性腎臟病相關之心肌病變進程的研究
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    Ongoing project

    Therapeutic targeting regulated cell death (necroptosis, pyroptosis, and ferroptosis)- activated necroinflammation to promote tissue repair following acute kidney injury

    調節性細胞死亡於腎臟組織損傷與修復過程的免疫活化機轉及其治療應用
  • Selected Publications

    2024

    1. Luo CH, Lai ACY, Tsai CC, Chen WY, Chang YS, Chung EJC, Chang YJ. Staphylococcus aureus exacerbates dermal IL-33-ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin. JCI Insight 2024 Feb 6:e166821. [Abstract]

     

    2022

    1. Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy L, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N*. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate 2 cells promotes obesity-associated hepatocellular carcinoma. Science Immunology.2022 Jun 24;7(72):eabl7209. [Abstract]
    2. Wang HH, Chen WY, Huang YH, Hsu SM, Tsao YP, Hsu YH, Chang MS*. Interleukin-20 is involved in dry eye disease and is a potential therapeutic target. Journal of Biomedical Sciences. 2022 Jun 9;29(1):36. [Abstract]
    3. Lu TC, Wu YH, Chen WY*, Hung YC*. Targeting oxidative stress and endothelial dysfunction using tanshinone IIA for the treatment of tissue inflammation and fibrosis. Oxidative Medicine and Cellular Longevity. 2022 Apr 7;2022:2811789. [Abstract]

    2021

    1. Kuo CF+, Chen WY+, Yu HH, Tsai YH, Chang YC, Chang CP, Tsao Nina*. IL-33/ST2 axis plays a protective effect in Streptococcus pyogenes infection through strengthening of the innate immunity. International Journal of Molecular Sciences. 2021 Sep 29;22(19):10566. [Abstract]
    2. Tzeng YR, Lee CH, Chen WY, Yang JL, Tzeng HT*. Inhibition of plasminogen activator inhibitor-1 blocks programmed death ligand 1 endocytosis and improves the response of melanoma cells to immune checkpoint blockade. Journal of Investigative Dermatology. 2021 Nov;141(11):2690-2698. [Abstract]
    3. Su CH, Hsu YC, Thangudu S, Chen WY, Huang YT, Yu CC, Shih YH, Wang CJ, Lin CL*. Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy. Scientific Reports. 2021, 11(1):1909. [Abstract]
    4. Chen WY *, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, Chang YJ*. Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics 2021, 11(6):2594-2611. [Abstract]

    2020

    1. Lu SW, Pan HC, Hsu YH, Chang KC, Wu LW, Chen WY, Chang MS*. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature Communications. 2020, 11(1):4611. [Abstract]
    2. Yang JL, Chen WY, Mukda S, Yang YR, Sun SF, Chen SD*. Oxidative DNA damage is concurrently repaired by BER and APE1-initiated NHEJ in cortical neurons. Neuropathology and Applied Neurobiology. 2020, 46(4):375-390. [Abstract]
    3. Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, Chang YJ*. Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy. 2020, 75(4):818-830. [Abstract]
    4. Chen WY *. Soluble alpha-Klotho alleviates cardiac fibrosis without altering cardiomyocytes renewal. International Journal of Molecular Sciences. 2020, 21(6). pii: E2186. [Abstract]
    5. Chen WY, Li LC, Wu YH, Yang JL, Tzeng HT*. Emerging roles of interleukin-33-responsive kidney group 2 innate lymphoid cells in acute kidney injury. International Journal of Molecular Sciences. 2020, 21(4). pii: E1544. [Abstract]

    2019

    1. Tsai TH, Lin CJ, Hang CL, Chen WY *. Calcitriol attenuates doxorubicin-induced cardiac dysfunction and inhibits endothelial-to-mesenchymal transition in mice. Cells. 2019, 8(8). pii: E865. [Abstract]
    2. Tsai TH, Lee CH, Cheng CI, Chua S, Chung SY, Chen, SM, Lin CJ, Wu CJ, Hang CL, Chen WY *. Liraglutide inhibits endothelial-to-mesenchymal transition and attenuates neointima formation after endovascular injury in streptozotocin-induced diabetic mice. Cells. 2019, 8(6). pii: E589. [Abstract]
    3. Sung HY, Chen WY, Huang HT, Wang CY, Chang SB, Tzeng SF. Downregulation of interleukin-33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression. Journal of Neurochemistry. 2019, 150(6):691-708. [Abstract]
    4. Weng YH+, Chen WY +, Lin YL, Wang JY*, and Chang MS*. Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology. 2019, 19:968. [Abstract]

    2018

    1. Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW, Vaghese Z, Chen WY *. Palmitate aggravates proteinuria-induced cell death and inflammation via CD36-inflammasome axis in the proximal tubular cells of obese mice. American Journal of Physiology-Renal Physiology 2018, 315(6) F1720-F1731. [Abstract]
    2. Chen WY *, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, Chang YJ*. IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury. Experimental and Molecular Medicine. 2018 Apr 20;50(4):1-11. [Abstract]

    2017

    1. Chen WY, Li LC, Yang JL*. Emerging roles of IL-33/ST2 axis in renal diseases. International Journal of Molecular Sciences. 2017, 18(4): pii: E783. [Abstract]

    2016

    1. Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD*. Activation of GLP-1 receptor enhances neuronal base excision repair via PI3K-AKT-induced expression of apurinic/apyrimidinic endonuclease 1. Theranostics. 2016, 6(12): 2015-2027. [Abstract]
    2. Su CH, Tsai CY, Tomanek B, Chen WY, Cheng FY*. Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications. Nanoscale. 2016, 8(15): 7866-7870. [Abstract]
    3. Chen WY *, Chang YJ, Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL*. Upregulation of Interleukin-33 in obstructive renal injury. Biochemical and Biophysical Research Communications. 2016, 473(4): 1026-1032. [Abstract]

    2015

    1. Chen WY, Hong J, Gannon J, Kakkar R, Lee RT*. Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33. Proceedings of the National Academy of Sciences of the United States of America. 2015, 112(23): 7249-7254. [Abstract]

    2005~2013

    1. Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C; CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. Journal of Clinical Investigation. 2013, 123(10): 4208-4218. [Abstract]
    2. Chen WY, Lee RT. Endothelial cardiac cell therapy: large-animal studies and the elephant in the room. Circulation Research. 2012, 111(7):824-6. [Abstract]
    3. Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. Journal of Experimental Medicine. 2011, 208(9):1849-61. [Abstract]
    4. Chen WY, Chang MS. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. Journal of Immunology. 182(8):5003-12. [Abstract]
    5. Chen WY, Cheng BC, Jiang MJ, Hsieh MY, Chang MS. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006, 26(9):2090-5. [Abstract]
    6. Chen WY, Cheng YT, Lei HY, Chang CP, Wang CW, Chang MS. IL-24 inhibits the growth of hepatoma cells in vivo. Genes and Immunity. 2005, 6(6):493-9. [Abstract]

  • Lab Members

    Current Members

    張佳琳(基醫所博士生, 2022-)

    陳嘉欣(生化所碩士生, 2022-)

    鍾嘉穎(生化所碩士生, 2022-)

    陳姿尹(生化所碩士生, 2023-)

    林羽唯(生化所碩士生, 2023-)

    莊正毅(醫學系專題生, 2022-)

    鍾明忠(醫學系專題生, 2022-)

    Alumni

    張雅婷(研究助理, 2014-2018)
    王宛貞(研究助理, 2015-2017)
    林璟吟(研究助理, 2019-2020)
    翁敬堯(研究助理, 2019-2020)
    吳逸修(博士後研究員, 2019-2022)
    李如芳(研究助理, 2015-2022)
    劉子維(研究助理, 2018-2022)
    戴玏昕(研究助理, 2015-2022)
    黃瑱芳(研究助理, 2017-2021)
    張佳琳(研究助理, 2022-2022)
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    Email: wychen624@gs.ncku.edu.tw

    Contact us for any potential collaborations

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